Instruments for miRNA in situ Hybridization (ISH):

BioGenex is a pioneer in the design, development and manufacturing of advanced systems for automation of cell and tissue-based staining. The Xmatrx research systems (NANO, MINI and Infinity) are the direct result of our platform technology innovation. They offer a variety of automation, throughput and assay applications for translational and clinical research. Our key technology differentiators, including the eXACT temperature control and reaction micro-chamber, enable any slide-based assays such as immunohistochemistry (IHC), in situ hybridization (ISH), fluorescence in situ hybridization (FISH), immuno-fluorescence (IF), co-detection and multiplex applications (double and triple stains; IHC/ISH), in situ PCR, micro-RNA and special staining.


1. Xmatrx® Elite and Xmatrx® Infinity:

Features & Benefits:

  • Intelligent and flexible system offering infinite possibilities – IHC, IF ISH, FISH, CISH, IF, Multiplexing and in situ PCR.
  • Simultaneous optimization of up to 40 parameters in single run
  • Reaction micro-chamber reduces micro-reagent consumption by up to 90%
  • 40 independent thermocyclable (PCR) workstations
  • Intuitive software designed for ease of use and flexibility
  • Reports for inventory management and regulatory compliance
  • Multiple slide processing options – Random, Continuous and STAT

2. NanoVIP:

Features & Benefits:

  • All-in-One – FISH, in situ PCR and ISH
  • Add micro-reagents manually to save cost
  • Economical and affordable
  • Flexible open system software – to create, edit and save protocols for future use
  • Run 10 different protocols simultaneously

3. Xmatrx® MINI:

Features & Benefits:

  • in situ PCR and FISH Work Station
  • Hybridizer with eXACT™ temperatures
  • 10 independent thermal cyclers
  • Built-in touch screen display for easy operations
  • On-board wash with effective waste drainage system
  • Audio-visual alerts at every step for manual intervention
  • User-friendly software with ability to add or delete cycles, store protocols for future use and perform up to 45 PCR cycles

4. Xmatrx® NANO:

Features & Benefits:

  • Add micro-reagents manually to save cost
  • Automated oil sealing and coverslipping to avoid reagent evaporation
  • eXACT temperature control on every slide
  • Open system software – create, edit and save protocols for future use
  • Run 10 different protocols simultaneously
Specifications Xmatrx® Infinity NanoVIP Xmatrx® MINI
Automation Full (baking through cover slip) Full Automation Work Station
Run Time (full slide load) Open System / User defined Open System / User defined Open System / User defined
Temperature Range Ambient to 105 oC Ambient to 105 oC Ambient to 105 oC
Reagent Dispensing Volume 10-850 µl 10-850 uL NA
Slide Capacity 40 10 10
Reagent Capacity 49 24 NA
Bulk Reagent Carboy 7 x 4 L 6 x 1 L NA
Waste Container 8 L 4 L 2 L
Languages enabled English English, Italian English, Italian
LIMS option
Protocols Template / Self Template / Self Template / Self
Dimensions (D/W/H) 29”/46”/59” 20”/30”/20” 19.5”/13”/8”
Weight 400 lb/ 182 kg 106 lb/ 48 kg 30 lb/ 13.6 kg


Research Platforms /Application IHC ISH/CISH Double Staining Special Stains FISH IF miRNA ISH Multiplexing


In Situ PCR
Xmatrx® Infinity
Xmatrx® MINI NA NA