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Instruments for In Situ Hybridization (ISH):

In situ Hybridization (ISH) is a powerful technique for precise detection and localization of a specific nucleic acid sequence within a histologic section. The underlying principle of ISH is that the nucleic acids within a histologic specimen can be detected by the hybridization of a complementary nucleic acid probe in which a reporter molecule is attached. Common non-radioactive labels for probe are fluorescein and digoxigenin. Subsequent visualization of the reporter molecule localizes DNA or RNA sequences in tissue or cells samples. ISH has broad applications such as chromosome mapping, karyotyping, and pathogen profiling. Nucleic acid probe also enables the localization and analysis of gene expression profile as well as other types of RNA such as microRNA and long non-coding RNA. 

 

Features & Benefits:

  • All-in-One – FISH, in situ PCR and ISH & IHC
  • Add micro-reagents manually to save cost/Option to apply micro reagents like probe and DAPI
  • Economical and affordable
  • Flexible open system software – to create, edit and save protocols for future use
  • Run 10 different protocols simultaneously

Features & Benefits:

  • High throughput – 100 slides per day (60 slides in eight hour shift and 40 slide in a overnight run) with overnight run option
  • Multiple slide processing options – Random, Continuous and STAT
  • Liquid level sensor for accurate dispensing and real time reagent tracking – avoid false results
  • Disposable tips – no cross-contamination
  • Onboard final coverslipping (proprietary)
  • Auto-DAB enabled
  • LIS interface
  • 2D Barcode-enabled scanning technology
  • Partial auto-drain waste disposal system
  • Removable Slide Racks with Splash Guard
  • Reaction micro-chamber with optimal microfluidics
  • 40 independent temperature control and protocols
  • Wide reagent volume dispense range(10µL-850µL)

Features & Benefits:

  • Intelligent and flexible system offering infinite possibilities – IHC, ISH, FISH, CISH, IF, Multiplexing and in situ PCR
  • Simultaneous optimization of up to 40 parameters in single run
  • Reaction micro-chamber reduces micro-reagent consumption by up to 90%
  • 40 independent thermocyclable (PCR) workstations
  • Intuitive software designed for ease of use and flexibility
  • Reports for inventory management and regulatory compliance
  • Multiple slide processing options – Random, Continuous and STAT

Features & Benefits:

  • in situ PCR and FISH Work Station
  • Hybridizer with eXACT™ temperatures
  • 10 independent thermal cyclers
  • Built-in touch screen display for easy operations
  • On-board wash with effective waste drainage system
  • Audio-visual alerts at every step for manual intervention
  • User-friendly software with ability to add or delete cycles, store protocols for future use and perform up to 45 PCR cycles

Features & Benefits:

  • Add micro-reagents manually to save cost
  • Automated oil sealing and coverslipping to avoid reagent evaporation
  • eXACT temperature control on every slide
  • Open system software – create, edit and save protocols for future use
  • Run 10 different protocols simultaneously
SpecificationsNanoVIP®Xmatrx® ELITEXmatrx® InfinityXmatrx® MINIXmatrx® NANO
AutomationFull AutomationFull (baking through coverslip)Full (baking through cover slip)Work StationWashing, coverslipping, slide drying
Run Time (full slide load)Open System / User definedClosed System / User definedOpen System / User definedOpen System / User definedOpen System / User defined
Temperature RangeAmbient to 105 oCAmbient to 105 oCAmbient to 105 oCAmbient to 105 oCAmbient to 105 oC
Reagent Dispensing Volume10-180 µl10-800 µL10-800 uLNANA
Slide Capacity1040401010
Reagent Capacity244949NANA
Bulk Reagent Carboy5 x 1 L7 x 4 L7 x 4 LNA6 x 1 L
Waste Container4 L8 L8 L2 L4 L
Languages enabledEnglishEnglishEnglishEnglishEnglish
LIMS option
ProtocolsTemplate / Self user definedPreloaded >400 protocolsTemplate / SelfTemplate / SelfTemplate / Self
Dimensions (D/W/H)20”/30”/20”29” x 66” x 59”29”/46”/59”19.5”/13”/8”20″ x 30″ x 15.7″
Weight106 lb/ 48 kg400 lb/182 Kg400 lb/ 182 kg30 lb/ 13.6 kg94 lb/43 Kg

 

Research Platforms /ApplicationIHCISH/CISHDouble StainingFISHIFmiRNA ISH

Multiplexing

(ISH + IHC)

In Situ PCR
NanoVIP®
Xmatrx® ELITENANANA
Xmatrx® Infinity
Xmatrx® MININA
Xmatrx® NANONANANANANA