Podoplanin (PDPN, T1A, gp38, Aggrus) is a 38 kDa type I single-pass transmembrane glycoprotein belonging to the type-1 family of sialomucin-like glycoproteins. It plays an important role in maintaining the unique shape of podocytes by regulating lymphatic endothelium and also involved in cell migration, metastasis formation and tumor cell invasion of tissue. Podoplanin is expressed in lymphatic epithelial cells, epithelioid mesotheliomas, seminomas, follicular DCs, thymic epithelial cells and stromal cells of peripheral lymphoid tissue. High expression of Podoplanin is observed in a number of tumor types including germ cell tumors, oral squamous cell carcinomas and colorectal cancers.
| Intended Use | IVD |
|---|---|
| Antibody Type | Cytoplasm and Membrane |
| Clone | D2-40 |
| Source | Mouse |
| Tissue Type/Cancer Type | Tonsil tissue |
| Pack | 1 mL – Manual – Concentrate, 0.5 mL – Manual – Concentrate, 6 mL – Manual – RTU, 10 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 50 tests – NanoVIP, 160 Tests – Automation – Xmatrx |
