PMS2 (Postmeiotic Segregation Increased 2) is one of the four major DNA mismatch repair (MMR) proteins along with MLH1, MSH2, and MSH6. It is crucial for maintaining genomic integrity by detecting and repairing errors that may occur during DNA replication. Mutations in these genes have been associated with microsatellite instability (MSI) which in turn develops Hereditary Non-Polyposis Colon Cancer (HNPCC) and several other cancers including endometrial cancer. Anti-PMS2 antibody is recommended to be used as a part of a panel for differentiating the gastrointestinal tract tumours, including HNPCC and associated extracolonic cancers.
|Tissue Type/Cancer Type||
Colon carcinoma tissue
1 mL – Manual – Concentrate, 0.5 mL – Manual – Concentrate, 6 mL – Manual – RTU, 10 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 50 tests – NanoVIP, 160 Tests – Automation – Xmatrx