PAX3 (Paired Box 3) is a DNA-binding protein consisting of an amino-terminal "paired" box domain and a paired-type homeodomain. It belongs to paired box (PAX) family of transcription factors and plays a critical role during fetal development. PAX3 is involved in development of peripheral nervous system, melanocytes, some vascular smooth muscle and are responsible for embryonic patterning and organogenesis. Mutations in PAX3 gene are associated with Waardenburg syndrome II (WSII), WSI/WSIII, alveolar rhabdomyosarcoma and craniofacial-deafness-hand syndrome.
Intended Use: IVD
Antibody Type: Nucleus
Clone: PAX3/4700
Source: Mouse
Tissue Type/Cancer Type: Ovary tissues