Poly ADP-Ribose Polymerase 1 (PARP-1), a 116 kDa nuclear DNA-binding zinc finger enzyme that influences DNA repair in response to environmental stress. It catalyses the transfer of ADP-ribose units from NAD (+) to a number of nuclear acceptor molecules including chromatin. Caspases mediates proteolysis of PARP1 into 24-kDa NH2-terminal peptide and 85 to 89-kDa COOH-terminal fragment that traverses into the cytoplasm. The appearance of PARP fragments facilitates cellular disassembly and serves as an early marker of programmed cell death (apoptosis).
|Tissue Type/Cancer Type||
Lymph node, Tonsil tissue
1 mL – Manual – Concentrate, 0.5 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 50 tests – NanoVIP, 100 Tests – Automation – i6000, 160 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual