Nucleophosmin (NPM1or nucleolar phosphoprotein B23 or numatrin) is a highly phosphorylated nucleolar protein involved in the assembly of ribosomal proteins into ribosome in nucleolus and maintenance of genome stability. A high level of nucleophosmin stimulates the growth of normal cells and is abundantly expressed in tumour cells than in normal resting cells. Mutations involving nucleophosmin were found in acute promyelocytic leukemia, acute myelogenous leukemia, nonHodgkin lymphoma and myelodysplastic syndrome.
Nucleus and Cytoplasm
|Tissue Type/Cancer Type||
Colon , Skin tissues
1 mL – Manual – Concentrate, 0.5 mL – Manual – Concentrate, 6 mL – Manual – RTU, 10 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 50 tests – NanoVIP, 160 Tests – Automation – Xmatrx