CDX2 (Caudal Type Homeobox 2) is a homeobox domain-containing transcription factor belongs to murine CDX family. It is an important protein in intestinal development, anterior to posterior patterning of the intestinal epithelium, proliferation and maintenance of the intestinal phenotype. CDX2 is localized in the nuclei of epithelial cells throughout the intestine. Expression of CDX2 is observed in primary and metastatic colorectal carcinomas, intestinal metaplasia of the stomach, intestinal-type gastric cancer, mucinous ovarian carcinomas, serous and endometrioid carcinomas.
|Tissue Type/Cancer Type||
Colon carcinoma, GIST tissues
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