CD10 (also known as Common Acute Lymphocytic Leukemia Antigen, CALLA, neutral endopeptidase (NEP) and Neprilysin) is a 100kDa type II integral membrane glycoprotein with neutral metalloendopeptidase activity. It is a zinc-dependent metalloprotease enzyme that cleaves and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, bradykinin, Angiotensins I and II. CD10 is expressed on early B and T lymphoid precursors, immature B cells with in adult bone marrow, breast myoepithelial cells, neutrophils, normal fibroblasts, bile canaliculi, fetal small intestine epithelium, brush border of the proximal tubules, glomerular epithelial cells, germinal cells in normal tonsil and lymphoid tissue. It is also expressed on cells of Burkitt’s, lymphoblastic and follicular germinal centre lymphomas, chronic myelocytic leukaemia (CML) and is useful marker for the characterization of common acute lymphocytic Leukaemia and B-cell Lymphomas.
| Intended Use | IVD |
|---|---|
| Antibody Type | Membrane and Cytoplasm |
| Clone | MME/6461 |
| Source | Mouse |
| Tissue Type/Cancer Type | Tonsil, Small intestine, Kidney tissues |
| Pack | 1 mL – Manual – Concentrate, 0.5 mL – Manual – Concentrate, 6 mL – Manual – RTU, 10 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 50 tests – NanoVIP, 160 Tests – Automation – Xmatrx |
