C4d (Complement 4d) is the final proteolytic remnant of the activated complement factor C4b. C4 is a component of the classical complement cascade, which is typically initiated by binding of antibodies to specific target molecules. The expression of C4d in peritubular capillaries is a crucial sign for acute humoral (i.e. antibody-mediated) rejection of kidney, pancreas, heart and lung allografts. Anti-C4d is considered as an important biomarker in organ transplants and used in the diagnosis of Acute Rejection and aggressive anti-rejection treatment.
| Intended Use | IVD |
|---|---|
| Antibody Type | Cytoplasm |
| Clone | SPM545 |
| Source | Mouse |
| Tissue Type/Cancer Type | Tonsil tissues |
| Pack | 1 mL – Manual – Concentrate, 0.5 mL – Manual – Concentrate, 6 mL – Manual – RTU, 10 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 50 tests – NanoVIP, 160 Tests – Automation – Xmatrx |
