DatasheetSDS

V-domain Ig suppressor of T cell activation (VISTA) is an inhibitory immune checkpoint protein mostly seen on tumor cells. VISTA in tumor cells suppresses T cell proliferation and cytokine production in vitro, and also decreased the tumor-infiltrating CD8+ T cells in vivo. It is primarily expressed in myeloid cells and also seen in CD4+, CD8+, and FoxP3+ T-cells. VISTA is highly expressed in human ovarian and an endometrial cancer is due to the methylation status of VISTA promoter.