Tyrosinase catalyses phenol oxidation and is generally present in plants and animals. Tyrosinase is a metallo enzyme containing copper, tyrosinase present in tissues catalyze oxidation of tyrosine and produces melanin and other pigments. The Microphthalmia- associated transcription factor gene regulates Tyrosinase. A tyrosinase gene mutation leads to mutated tyrosinase production uncapable of tyrosine oxidation that results in type I oculocutaneous albinism, a hereditary disease that one in every 17,000 person has in the US. Anti-Tyrosinase has been found to be quite specific for melanotic lesions such as malignant melanoma, and melanotic neurofibroma. Essentially no carcinomas express this marker
| Intended Use | IVD |
|---|---|
| Antibody Type | Monoclonal |
| Clone | Ty/G5 |
| Source | Mouse |
| Tissue Type/Cancer Type | Melanoma |
| Pack | 0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 160 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual |
