Tyrosinase catalyses phenol oxidation and is generally present in plants and animals. Tyrosinase is a metallo enzyme containing copper, tyrosinase present in tissues catalyze oxidation of tyrosine and produces melanin and other pigments. The Microphthalmia- associated transcription factor gene regulates Tyrosinase. A tyrosinase gene mutation leads to mutated tyrosinase production uncapable of tyrosine oxidation that results in type I oculocutaneous albinism, a hereditary disease that one in every 17,000 person has in the US. Anti-Tyrosinase has been found to be quite specific for melanotic lesions such as malignant melanoma, and melanotic neurofibroma. Essentially no carcinomas express this marker
Intended Use: IVD
Antibody Type: Monoclonal
Clone: Ty/G5
Source: Mouse
Tissue Type/Cancer Type: Melanoma

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