Tumor-Associated Glycoprotein 72 (TAG-72) is an oncofetal mucin antigen expressed by normal secretory endometrium and colorectal, gastric, pancreatic, mammary, and most human adenocarcinomas ovarian. Antibody B72.3 identifies and binds to a carbohydrate epitope identified as sialylated Tn antigen. sialylated Tn antigen is generally expressed by invasive ductal breast carcinomas, ovarian and colon, pancreatic, gastric, esophageal, lung, ?endometrial adenocarcinomas. This antigen is not expressed by leukemias, lymphomas, sarcomas, mesotheliomas, melanomas, or benign tumors. This antigen is also expressed on normal secretory endometrium, but not on other normal tissues. TAG-72 expression in fetal tissue is only observed in tissues of the gastrointestinal tract, including the colon, esophagus and stomach. No reactivity is seen with tissue from other organ systems, including the lymphoreticular, cardiovascular, hepatic, pulmonary, neural, muscular, skin, endocrine and genitourinary tissues.
|Tissue Type/Cancer Type|
0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 160 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual