Thyroid Transcription Factor-1 (TTF-1) or thyroid-specific enhancer-binding protein (T/EBP), with a molecular weight of 40 kD is a NKx2 family member protein, it is homeodomain transcription factor specifically regulating the gene expression of lung- and thyroid tissues . It is a very selective marker for adenocarcinomas of lung and thyroid origin. Nuclear localization of this protein is seen in the epithelial cells of thyroid gland and lung (2). The anti-TTF-1 antibody is a useful tool for differentiating pulmonary adenocarcinoma from metastatic breast carcinoma and mesothelioma.
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0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 200 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual