Thyroid Transcription Factor-1 (TTF-1) or thyroid-specific enhancer-binding protein (T/EBP), with a molecular weight of 40 kD is a NKx2 family member protein, it is homeodomain transcription factor specifically regulating the gene expression of lung- and thyroid tissues . It is a very selective marker for adenocarcinomas of lung and thyroid origin. Nuclear localization of this protein is seen in the epithelial cells of thyroid gland and lung (2). The anti-TTF-1 antibody is a useful tool for differentiating pulmonary adenocarcinoma from metastatic breast carcinoma and mesothelioma.
| Intended Use | IVD |
|---|---|
| Antibody Type | Monoclonal |
| Clone | BGX-397A |
| Source | Mouse |
| Tissue Type/Cancer Type | Thyroid |
| Pack | 0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 160 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual |
