Thyroid Transcription Factor-1 (TTF-1), also known as thyroidspecific enhancer-binding protein (T/EBP), is a 40 kD protein that is a member of NKx2 family of homeodomain transcription factors that regulates the expression of thyroid- and lung-specific genes. It is a very selective marker for adenocarcinomas of lung and thyroid origin. Nuclear localization of this protein is seen in the epithelial cells of thyroid gland and lung. The anti-TTF-1 antibody is a useful tool for differentiating pulmonary adenocarcinoma from metastatic breast carcinoma and mesothelioma.
| Intended Use | IVD |
|---|---|
| Antibody Type | Monoclonal |
| Clone | NX2.1/690 |
| Source | Mouse |
| Tissue Type/Cancer Type | Lung cancer |
| Pack | 6 mL (RTU), 100 Tests – Automation – i6000, 1 mL(Conc.), 0.5 mL (Conc.), 160 tests – Xmatrx Elite, 50 tests – Xmatrx Elite, 5 slides ? Xmatrx, 5 slides ? Manual |
