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Thyroid transcription factor-1 (TTF-1) is a sensitive marker for diagnosis of primary pulmonary adenocarcinoma, and differentiation between poorly differentiated squamous cell carcinoma and small cell carcinoma and adenocarcinoma. Gross cystic disease fluid protein (GCDFP-15) is currently used as an immunohistochemical marker of breast cancer. TTF-1/GCDFP15 immunohistochemical profile in lung tumors is highly suggestive of metastatic carcinoma of the breast. In distinguishing metastatic breast carcinoma and adenocarcinoma of the lung, the cytoplasmic staining would indicate breast carcinoma and nuclear staining would indicate lung or thyroid carcinoma.