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Thyroid Transcription Factor-1 (TTF-1), also known as thyroidspecific enhancer-binding protein (T/EBP), is a member of NKx2 family of homeodomain transcription factors that regulates the expression of thyroid- and lung- specific genes. It is a very selective marker for adenocarcinomas of lung and thyroid origin. Nuclear localization of this protein is seen in the epithelial cells of thyroid gland and lung, whereas several other organs were found to be TTF-1-negative. The Anti-TTF-1 antibody is a useful tool for differentiating pulmonary adenocarcinoma from metastatic breast carcinoma and mesothelioma. A more recent study has demonstrated the presence of TTF-1 in fetal and adult rat hypothalami.