TRPS-1 (Trichorhinophalangeal syndrome 1), a GATA transcription factor, is highly prevalent in both Estrogen Receptor alpha (ERα+ and ERα−) breast cancer subtypes. It plays a crucial role in mesenchymal-to-epithelial transition during development and differentiation of various tissues, including cartilage, bone, kidney, and hair follicles. Identified as a regulator of normal mammary epithelial cell growth, TRPS-1 is implicated in breast cancer development. Importantly, it exhibits minimal expression in various other carcinomas, indicating its specificity for breast cancer, especially in triple-negative breast cancer (TNBC). These findings emphasize TRPS-1's importance as a specific and valuable marker for breast cancer, especially in the context of TNBC.      
Regulatory Claim: IVD for Both
Clone: TRPS1/8131R
Isotype: IgG, kappa
Localisation: Nuc
Source: Rabbit
Control Tissue: Breast Tissue