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Anti-Transthyretin, CloneTTR/4292

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Product Description

Transthyretin (TTR), previously called thyroxin-binding Prealbumin, is a 55 kDa homotetramer of 14-15 kDa monomers that is found in plasma. It is a homo-tetrameric carrier protein, which transports thyroid hormones in the plasma and cerebrospinal fluid. It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinol-binding protein. This protein may also be involved in other intracellular processes including proteolysis, nerve regeneration, autophagy and glucose homeostasis. Mutations in this gene are associated with amyloid deposition, predominantly affecting peripheral nerves or the heart, while a small percentage of the gene mutations are non-amyloidogenic. These mutations lead to a number of diseases, including amyloidotic polyneuropathy, amyloidotic vitreous opacities, euthyroid hyperthyroxinaemia, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, and carpal tunnel syndrome. In Immunohistochemistry of normal tissue, TTR has secretory positivity in plasma and is also found in the liver, the brain, in pancreatic islets and in renal tubules

Intended Use

IVD

Antibody Type

Monoclonal

Clone

TTR/4292

Source

Mouse

Tissue Type/Cancer Type

Liver tissue

Pack

6 mL (RTU), 100 Tests – Automation – i6000, 1 mL(Conc.), 0.5 mL (Conc.), 160 tests – Xmatrx Elite, 50 tests – Xmatrx Elite, 5 slides – Xmatrx, 5 slides – Manual