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T-cell immunoglobulin and mucin domain 3 (TIM3) is a member of immunoglobulin (Ig) and mucin domain (TIM) family, comprised of type-I cell surface glycoproteins. TIM3 expressed on interferon (IFN)-gamma (γ) secreting helper T (Th) cells, regulatory T cells (Tregs), CD8 + T cells, Dendritic cells (DCs), monocytes, and other leukocyte subsets, including natural killer (NK) cells. TIM3 plays a key role in inhibiting both adaptive and innate immune responses, potentially exerting either positive or negative effects, thus acting as an immune modulator. In chronic inflammation, autoimmune disorders, and some cancers, While on activated T cells, CEACAM1 and Tim3 are co-expressed and form a heterodimer to suppress T cell function and down regulate its anti-tumor immunity.