The T cell intracellular antigen 1 (TIA-1) is a cytoplasmic granule associated protein of molecular weight 17-kDa and it is also abbrevated as GMP-17 for granule membrane protein. The T-cytotoxic cells express GMP-17/TIA-1 molecule on the cell curface and this enables the cell to possess cytolytic potential and by Fas (CD95)-signaling cascade mediated apoptosis. The 2G9 monoclonal antibody (mAb) identifies and binds to normal peripheral blood lymphocytes (90% of CD16+, 50 ? 60% of CD8+, and less than 10% of CD4+) within hematopoietic cell lines. It identifies and binds to all granulocytes and monocytes. This antibody does not react with B lymphocytes or B-cell lines but reacts with CD4+ activated T-cell clones, activated NK cell clones, and Con A – activated thymocytes. The 2G9 mAb was evaluated during the 5th HLDA Workshop on Human Leucocyte Differentiation Antigens in, Boston, USA, in 1993 (section of monoclonal antibodies reactive with intracellular antigens).
| Intended Use | IVD |
|---|---|
| Antibody Type | Monoclonal |
| Clone | 2G9A10F5 |
| Source | Mouse |
| Tissue Type/Cancer Type | Anaplastic Large |
| Pack | 0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 160 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual |
