The T cell intracellular antigen 1 (TIA-1) is a cytoplasmic granule associated protein of molecular weight 17-kDa and it is also abbrevated as GMP-17 for granule membrane protein. The T-cytotoxic cells express GMP-17/TIA-1 molecule on the cell curface and this enables the cell to possess cytolytic potential and by Fas (CD95)-signaling cascade mediated apoptosis. The 2G9 monoclonal antibody (mAb) identifies and binds to normal peripheral blood lymphocytes (90% of CD16+, 50 ? 60% of CD8+, and less than 10% of CD4+) within hematopoietic cell lines. It identifies and binds to all granulocytes and monocytes. This antibody does not react with B lymphocytes or B-cell lines but reacts with CD4+ activated T-cell clones, activated NK cell clones, and Con A - activated thymocytes. The 2G9 mAb was evaluated during the 5th HLDA Workshop on Human Leucocyte Differentiation Antigens in, Boston, USA, in 1993 (section of monoclonal antibodies reactive with intracellular antigens).
Intended Use: IVD
Antibody Type: Monoclonal
Clone: 2G9A10F5
Source: Mouse
Tissue Type/Cancer Type: Anaplastic Large

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