DatasheetSDS

Transcription factor E3 (TFE3) is a member of a family of basic helix-loop-helix leucine zipper transcription factors that includes MITF, TFEB, TFE3, and TFEC. Transcription factor binding to IGHM enhancer 3 or transcription factor E3 (TFE3) gene is mapped to human chromosome Xp11.23. In the immune system,
TFE3 plays important roles in modulating immunoglobulin heavy-chain expression and regulating B-cell activation. Members of this family form heterodimers with each other, bind the same DNA sequences, and undergo the same types of posttranslational modifications; including sumoylation .This gene may be involved in chromosomal translocations that occur in a number of tumors, including sporadic renal cell tumors alveolar soft part sarcoma, perivascular epithelioid cell tumor, and epithelioid hemangioendotheliomas. TFE3 antibody is the most sensitive and specific immunohistochemical marker for the RCC Xp11.2 translocation, which reflects over-expression of the resulting fusion proteins relative to native TFE3.