DatasheetSDS

The Tau protein is expressed in axonal compartments of neurons. Tau protein plays an crucial role in the assembly of monomer tubulin into microtubules to form the neuronal microtubule network. Tau?s major role is to regulate neuronal microtubule assembly and stability thus playing a major role in movement disorders. One of the histopathological markers of Alzheimer?s disease are Neurofibrillary tangles (NFTs), show signs of heavily incorporated Tau protein. Anti-Tau antibody binds Neurofibrillary tangles (NFTs) to show a strong positive staining in NFT areas and may also stain Pick bodies in Pick?s disease. Filamentous tau protein deposits are also the defining characteristics for progressive supranuclear palsy, and corticobasal degeneration. In normal tissue, the antibody may stain neurons and axons in the brain and spinal cord