DatasheetSDS

Synaptophysin is a 38 kDa major integral four pass transmembrane glycoprotein present on synaptic vesicles. This protein is present in almost all neurons and neuroendocrine cells throughout the body. Synaptophysin is found in the trans-Golgi region and in the presynaptic vesicles of neurons and the smooth-surfaced vesicles of neuro-endocrine cells of the gut, pancreatic islets, pheochromocytomas, adrenal medulla. Synaptophysin is a sensitive quantitative molecular marker of synaptic density and also a useful marker in the identification and characterization of neuronal and neuroendocrine neoplasms of the adrenal medullary, pituitary, thyroid and islet cell tumors, gastrointestinal, bronchial, thymic and pancreatic carcinoid tumors. Immunohistochemistry of synaptophysin has been used in the evaluation of functional bowel disorders, cortical epileptogenesis, schizophrenia and amyotropic lateral sclerosis. An antibody to Synaptophysin is useful for the identification of tumors with neural and neuroendocrine differentiation.