Simian virus (SV40) T (large and small) antigens are encoded by the early region of the SV40 genome. The large T antigen of SV40 binds DNA, and complexes with a 53KDa cellular protein, p53, which is required for initiation of viral DNA replication during lytic growth. In addition, it also binds DNA polymerase and the transcription factor AP-2 to form a specific complex with the P105 product of the retinoblastoma susceptibility gene. SV40 also forms complexes with a second tumor supressor gene-encoded protein, Rb 105.
6 mL (RTU), 10 mL (RTU), 1 mL(Conc.), 0.5 mL (Conc.), 200 tests – Xmatrx Elite, 50 tests – Xmatrx Elite, 5 slides – Xmatrx, 5 slides – Manual