Anti-SV40 T Ag [Pab 101]


Simian virus (SV40) T (large and small) antigens are encoded by the early region of the SV40 genome. The large T antigen of SV40 binds DNA, and complexes with a 53KDa cellular protein, p53, which is required for initiation of viral DNA replication during lytic growth. In addition, it also binds DNA polymerase and the transcription factor AP-2 to form a specific complex with the P105 product of the retinoblastoma susceptibility gene. SV40 also forms complexes with a second tumor supressor gene-encoded protein, Rb 105.
Intended Use: IVD