Substance P (SP) is a neuroendocrine polypeptide localized in both the nervous system and gastrointestinal tract and it is secreted by nerves and inflammatory cells such as macrophages, eosinophils, lymphocytes, and dendritic cells, it acts by binding to the neurokinin-1 receptor (NK-1R). Substance P along with bombesin and neurotensin grouped into a family since they?re localized in both brain and gut and posses a common dipeptide sequence (-Leu-Met-NH 2 ) at the amino terminal end. Substance P is found localized in mid-gut and about half of fore-gut and hind-gut intestinal carcinoids. This antibody cross-reacts with other species Substance P including chicken and opossum.
|Tissue Type/Cancer Type|
0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 200 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual