DatasheetSDS

SOX9 is a member of SOX (SRY-like HMG box) family of transcription factors with diverse roles in development. SOX9 involved in chondrogenesis and regulates the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes. In addition, it is reportedly involved in the maintenance of adult stem cell populations, including multipotent neural stem cells, hair follicle stem cells, and mammary stem cells. It plays an important role in sex determination and differentiation of Sertoli cells. The expression of sox9 is seen in the central nervous system, neural crest, intestine, salivary gland, and testis. Sox9 expression has been reported in several other tumor types including ovarian, prostate, and pancreatic malignancies.