SOX2 or SRY related HMG BOX gene 2 is a transcription factor belongs to the SRY-related HMG-box (SOX) and it is involved in the regulation of embryonic development, determination of cell fate. SOX2 factor is critical for stem cell potency in the central nervous system, and it also regulates gene expression in the stomach. SOX2 is necessary for Oct3/4 regulation, expression . An essential function of SOX2 is to stabilize embryonic stem cells in a pluripotent state by maintaining the requisite level of Oct3/4 expression. Structurally SOX proteins posses a single HMG box and bind to linearized DNA in a sequence-specific manner, results in the bending of DNA through large angles. Bending results in DNA helix to open, it affects binding and interactions of other transcription factors. SOX1, SOX2 and SOX3 show the closest homology to SRY. They share maximum homology within the HMG domain and are expressed mainly in the developing nervous system of the mouse. These genes share significant homology outside the HMG box also and are highly conserved throughout their evolution?
|Tissue Type/Cancer Type|
0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 200 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual