Somatostatin also designated as SST or SMST or growth hormone inhibiting hormone (GHIH) or somatotropin releaseinhibiting factor (SRIF), is a 116 amino acid (aa) peptide hormone that is expressed throughout the body. It has both regulatory and inhibitory function. Somatostatin plays an important role in regulating the endocrine system, affecting neurotransmission and inhibiting cell proliferation. It binds to high-affinity G-protein-coupled somatostatin receptors and inhibits the release of numerous secondary hormones. Somatostatin is secreted by the cells of hypothalamus, sympathetic nerves, mucosal cells, myenteric nerves of the gastrointestinal tract, delta cells of the pancreas, salivary glands and by some parafollicular cells of the thyroid.
|Tissue Type/Cancer Type||
Pancreas, Duodenum, Stomach, tissues
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