SMAD4, also designated as DPC4 or SMAD family member n°4, is a DNA-binding protein that belongs to the SMAD family of transcription factors. It also defined as a signal transducer and forms complexes with other members of the SMAD family. Activated SMAD4 complexes accumulate in the nucleus and serves as a mediator between extracellular growth factors from the TGFβ family and genes inside the cell nucleus. It is implicated as downstream effectors of TGFβ/BMP signalling which negatively regulates growth of epithelial cells and the extracellular matrix (ECM). SMAD4 expression is found in skin, Pancreatic, colon, uterus and epithelial cells. Mutations in SMAD4 have been found in multiple cancers including cholangiocarcinoma, colorectal, head and neck, and pancreatic cancer.
Intended Use: IVD
Antibody Type: Monoclonal
Clone: rSMAD4/6310
Source: Mouse
Tissue Type/Cancer Type: Pancreatic Adenocarcinoma

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