Sal-like protein 4 (SALL4) is a zinc-finger transcription factor highly expressed during development. Sall4 is expressed very early in development with other pluripotency regulators, such asOct-4 and Nanog. It serves as a master regulator of embryonic pluripotency by modulating Oct4 and is involved in processes associated with stem cell activities. SALL4 expression in germ cells makes it a useful sensitive and specific diagnostic marker for germ cell tumors such as seminomas, embryonal carcinoma, and yolk sac tumors. SALL4 expression is also seen in the spermatogonia of normal testis. Anti-SALL4 antibody also stains most cases of teratoma and the mononucleated trophoblastic cells in choriocarcinomas.
| Intended Use | IVD |
|---|---|
| Pack | 6 mL (RTU), 10 mL (RTU), 1 mL(Conc.), 0.5 mL (Conc.), 200 tests – Xmatrx Elite, 50 tests – Xmatrx Elite, 5 slides – Xmatrx, 5 slides – Manual |
