RRM1 (Ribonucleotide reductase M1) a 90kDa polypeptide is one of two non-identical subunits of ribonucleoside-diphosphate reductase (RNR), an enzyme essential for the synthesis of de novo deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is the largest subunit of RNR and is present throughout the cell division cycle but downregulated in non-dividing quiescent cells.RRM1 is found to be involved in tumor progression and carcinogenesis, and its expression is correlated with resistance to chemotherapy in non-small cell lung cancer.
| Intended Use | IVD |
|---|---|
| Antibody Type | Monoclonal |
| Clone | RRM1/4372R |
| Source | Rabbit |
| Tissue Type/Cancer Type | Colon Carcinoma Tissue |
| Pack | 0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 160 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual |
