RRM1 (Ribonucleotide reductase M1) a 90kDa polypeptide is one of two non-identical subunits of ribonucleoside-diphosphate reductase (RNR), an enzyme essential for the synthesis of de novo deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is the largest subunit of RNR and is present throughout the cell division cycle but downregulated in non-dividing quiescent cells.RRM1 is found to be involved in tumor progression and carcinogenesis, and its expression is correlated with resistance to chemotherapy in non-small cell lung cancer.
Intended Use: IVD
Antibody Type: Monoclonal
Clone: RRM1/4372R
Source: Rabbit
Tissue Type/Cancer Type: Colon Carcinoma Tissue