Retinoblastoma gene / protein. Tumor suppressor gene at 13q14 it Encodes a 110-114 kDa nuclear protein that plays an important role in cell cycle progression by regulating cell cycle arrest at G1-S. Retinoblastoma (Rb) is a rare tumor of retina with mutations at chromosome 13Activation of ATF-2 initiates’ expression of TGF-beta2 which in turn inhibits transcription of genes affecting cell growth. Bilateral mutation of the Rb gene may play a role in the development of malignant tumors.
6 mL (RTU), 10 mL (RTU), 1 mL(Conc.), 0.5 mL (Conc.), 200 tests – Xmatrx Elite, 50 tests – Xmatrx Elite, 5 slides – Xmatrx, 5 slides – Manual