Pygopus 2 (also designated as PYGO2) is a 41 kDa, 406 amino acid transcriptional Coactivator. It contains three domains- an N terminal NLS, a proline-rich region and a zinc-finger PHD-type domain that is involved in Wnt signaling pathway. Pygopus 2 is localized to nucleus and acts in concert with BCL-9 and TCF to retain beta -Catenin during Wnt-signaling. Pygopus 2 overexpression enhances primary tumor growth and local invasion to draining lymph nodes in breast carcinoma, Prostate carcinoma, advanced NSCLC, gliomas, Colorectal Carcinomas.
| Intended Use | IVD |
|---|---|
| Antibody Type | Monoclonal |
| Clone | B-12 |
| Source | Mouse |
| Tissue Type/Cancer Type | Tonsil Tissue |
| Pack | 0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 160 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual |
