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Anti-PU.1

SKU: AN843GP Categories: , , ,
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Product Description

PU.1 is a transcription factor of ETS (E26 transformation-specific) family; it is required for hematopoiesis. It has a critical role in differentiation of normal myeloid progeny, and regulates the immunoglobulin gene expression and other genes that are significant for B cell development. PU.1 stains B lymphocyte in germinal center and mantle B cell, but not plasma cell. It labels many types of B cell lymphoma including mantle cell lymphoma, but it is not expressed in classical Hodgkin lymphoma (cHL). The lack of transcription factor PU.1 protein expression in cHL, a lympho- proliferative disease of predominantly B-cell origin, likely contributes to the lack of immunoglobulin expression and incomplete B-cell phenotype characteristic of the Reed-Sternberg cells in cHL.

Intended Use

IVD

Antibody Type

Monoclonal

Clone

EP18

Source

Rabbit

Tissue Type/Cancer Type

Lymphoma

Pack

0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 200 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual