PU.1 is a transcription factor of ETS (E26 transformation-specific) family; it is required for hematopoiesis. It has a critical role in differentiation of normal myeloid progeny, and regulates the immunoglobulin gene expression and other genes that are significant for B cell development. PU.1 stains B lymphocyte in germinal center and mantle B cell, but not plasma cell. It labels many types of B cell lymphoma including mantle cell lymphoma, but it is not expressed in classical Hodgkin lymphoma (cHL). The lack of transcription factor PU.1 protein expression in cHL, a lympho- proliferative disease of predominantly B-cell origin, likely contributes to the lack of immunoglobulin expression and incomplete B-cell phenotype characteristic of the Reed-Sternberg cells in cHL.
Intended Use: IVD
Antibody Type: Monoclonal
Clone: EP18
Source: Rabbit
Tissue Type/Cancer Type: Lymphoma