DatasheetSDS

PTEN gene encodes Phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase (PTEN), is a tumor suppressor and a key component in the PI3K/PTEN/Akt pathway. It contains domains similar to that of the dual specificity protein tyrosine phosphatases. PTEN phosphatase protein preferentially dephosphorylates phosphoinositide substrates, unlike most of the protein tyrosine phosphatases. The defects of PTEN gene have been implicated in human cancers from breast, prostate, thyroid, skin, endometrium, head and neck, and brain. PTEN gene shows abnormal PTEN gene expression or loss of protein expression in advanced prostate cancers