Anti-PTEN, Clone 6H2.1


Phosphatase and tensin homologue deleted on chromosome TEN (at 10q23) (PTEN) is a tumor suppressor and a member in the PI3K/PTEN/Akt pathway. PTEN gene encodes a 403 amino acid cytosolic lipid phosphatase that negatively regulates AKT activity by dephosphorylating phosphatidylinositol 3,4,5-trisphosphate (PIP3). The defects of PTEN have been implicated in human cancers from breast, prostate, thyroid, skin, endometrium, head and neck, and brain. Up to 50-60 percent of advanced prostate cancers show abnormal PTEN gene expression or loss of protein expression.
Intended Use: IVD