The human progesterone receptor (PR), is a ligand-activated transcription factor and is a member of the steroid receptor family. PR exists in human as two isoforms; PR-A (94 kDa) which lacks the first 164 amino acids of PR-B and PR-B(114 kDa). While the two forms of PR have similar DNA and Ligand binding affinities they have opposite transcriptional activities PR-B functions as an activator of progesterone-responsive genes, while PR-A functions as a strong transdominant repressor of PR-B. This anti-PR recognizes both PR-A and B. It labels epithelial cells of breast, ovary and endometrium.
|Tissue Type/Cancer Type|
0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 200 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual