Anti-Progesterone Receptor (PR)


The human progesterone receptor (PR), is a ligand-activated transcription factor and is a member of the steroid receptor family. PR exists in human as two isoforms; PR-A (94 kDa) which lacks the first 164 amino acids of PR-B and PR-B(114 kDa). While the two forms of PR have similar DNA and Ligand binding affinities they have opposite transcriptional activities PR-B functions as an activator of progesterone-responsive genes, while PR-A functions as a strong transdominant repressor of PR-B. This anti-PR recognizes both PR-A and B. It labels epithelial cells of breast, ovary and endometrium.
Intended Use: IVD
Antibody Type: Monoclonal
Clone: EP2
Source: Rabbit
Tissue Type/Cancer Type: Breast Ca