PIT-1 (Pituitary-specific transcription factor 1) also known as POU1F1, GHF-1 (Growth hormone factor 1), CPHD1, is a transcription factor belongs to POU homeodomain family. It is essential for the anterior pituitary gland development and hormone expression in mammals. PIT1 is also important for regulation of five distinct hormone-producing cell lineages, including somatotropes, lactotropes, thyrotropes, corticotropes, and gonadotropes. Loss of Pit-1 expression results in combined pituitary hormone deficiency (CPHD) of growth hormone, Prolactin and thyroid stimulating hormone. PIT-1 is also expressed in human breast and its upregulation leads to breast cancer metastasis.
|Tissue Type/Cancer Type||
Pituitary, Tonsil, Thyroid tissues
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