This antibody reacts with a 20-30kDa protein, identified as PGP9.5, also known as ubiquitin UchL1. PGP9.5 is highly expressed in neurons and to cells of the diffuse neuroendocrine system and their tumors. It is abundantly present in all neurons (accounts for 1-2% of total brain protein), expressed specifically in neurons and testis/ovary. Although PGP9.5 protein expression is specific to neurons and testis/ovary tissue, it has been found to be expressed in certain lung-tumor cell lines. This abnormal expression of PGP9.5 is implicated in cancer and has led to the designation of PGP9.5 as an oncogene. Immunostaining for PGP9.5 has been shown in a wide variety of mesenchymal neoplasms as well. A mutation in PGP9.5 gene is believed to cause a form of Parkinson’s disease.
|Tissue Type/Cancer Type|
6 mL (RTU), 10 mL (RTU), 1 mL(Conc.), 0.5 mL (Conc.), 160 tests – Xmatrx Elite, 50 tests – Xmatrx Elite, 5 slides – Xmatrx, 5 slides – Manual