DatasheetSDS

PDGFR-β (Platelet-derived growth factor receptor-beta) also designated CD140B antibody, is a cell surface tyrosine kinase receptor for the members of Platelet-derived growth factor receptor. These are mitogens for mesenchymal and glia derived cells and regulate diverse cellular functions by binding to and inducing the homo- and heterodimerization of two receptors (alpha and beta). It plays an important role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Also, it is considered to be essential for endothelial proliferation, migration and recruitment of pericytes and smooth muscle cells to form blood vessels. It is essential for normal development of the cardiovascular system and aids in arrangement of actin cytoskeleton. The PDGF beta receptors are expressed in myoblasts, capillary endothelial cells, pericytes, T-cells, myeloid hematopoietic cells and macrophages.