PD-L1 (Programmed death ligand 1) or B7 homolog 1 (B7-H1) is immunoglobulin-like type I transmembrane glycoprotein that acts as a ligand for programmed death 1 (PD-1). PD-L1 upon interaction with its receptor PD-1 delivers inhibitory signals to activated T cells and B cells and thus helps to maintain the balance between effective immunity, tolerance and immunopathology. In a tumor microenviroment, cancer cells upregulate PD-L1 expression – this PD-1/PDL-1 interaction axis helps in evading anti-tumor responses and promotes cancer-associated immune suppression.
| Intended Use | IVD |
|---|---|
| Antibody Type | Monoclonal |
| Clone | IHC411 |
| Source | Rabbit |
| Tissue Type/Cancer Type | Tonsil, Lung Adenocarcinoma |
| Pack | 0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 160 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual |
