PD-L1 (Programmed death ligand 1) or B7 homolog 1 (B7-H1) is immunoglobulin-like type I transmembrane glycoprotein that acts as a ligand for programmed death 1 (PD-1). PD-L1 upon interaction with its receptor PD-1 delivers inhibitory signals to activated T cells and B cells and thus helps to maintain the balance between effective immunity, tolerance and immunopathology. In a tumor microenviroment, cancer cells upregulate PD-L1 expression - this PD-1/PDL-1 interaction axis helps in evading anti-tumor responses and promotes cancer-associated immune suppression.
Intended Use: IVD
Antibody Type: Monoclonal
Clone: IHC411
Source: Rabbit
Tissue Type/Cancer Type: TonsilLung Adenocarcinoma

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