DatasheetSDS

Paxillin is a multidomain cytoskeletal protein with a role in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Paxillin?s C- terminal region consist of four LIM domains that interacts with cytoplasmic tail of beta-integrin to target paxillin to focal adhesion. ?The signaling activity of is controlled by N-terminus of Paxillin. Epithelial cells of various tissues, neuronal cells and mesenchymal derived cells express Paxillin. It has been reported that Paxillin is involved in tumor invasion and ? metastasis. Its expression in lung and liver cancers has been correlated with advanced tumor stage and metastasis. ?An antibody to Paxillin is helpful in differentiating between renal cell carcinoma (Paxillin negative) and chromophobe renal cell carcinoma or renal oncocytoma (Paxillin positive), which are rare renal tumors originating from the intercalated cells of collecting ducts